Dehumidification and Capsule Storage

As a dosage form, capsules have been around for a long time. The first recorded patent for gelatine capsule production was in 1834. It would be reasonable to assume that after some 180 years of experience there would be no secrets about how to achieve optimal capsule quality and consistency. While that assumption is mostly true, things have also changed since the first capsules were produced. New technologies have entered the production space, formulations and ingredients have changed to meet market demands, and even the climate itself has changed with seasonal temperature and humidity reaching new levels. One thing that has definitely changed and will also continue to develop, is the need to produce capsules with consistent quality characteristics, particularly when producing GMP compliant products. Not surprisingly, humidity control during the drying and storage processes plays a large role in achieving quality targets.